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1510 SE 9th Ave., 888-643-8669, portland.heliumcomedy.com.
This is where you see major comedians like Chelsea Peretti and Mike Epps take the stage following openers made up of the funniest people in Portland. The city's premier comedy club also happens to sit on the same block as Farma, the dispensary most frequently voted Portland's best. You can't smoke inside of either establishment, but necessity is the mother of…a strategic stroll.